Mage

Cassiopeia

The Serpent's Embrace

Cassiopeia is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power.Read the full story on Riot's Universe site

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P
Serpentine Grace
Q
Noxious Blast
W
Miasma
E
Twin Fang
R
Petrifying Gaze

Cassiopeia

Overview

On patch 16.21, Cassiopeia is rated D tier in the mid lane, winning 45% of 733 ranked games with a 0.8% pick rate. The most successful build this patch runs Stormraider's Surge with Flash and Ghost and builds Seraph's Embrace, Rod of Ages, Rylai's Crystal Scepter, and Swiftmarch.

Cassiopeia struggles most against Vladimir (22.2%), Veigar (28.6%), and Fizz (40%) and does best against Malzahar (66.7%), Zed (54.5%), and Katarina (52.9%).

Ranked solo/duo · patch 16.21 · 733 games · updated Nov 1, 2026 · How we calculate

45%

Win rate

0.8%

Pick rate

733

Games

16.21

Patch

Playing as Cassiopeia

Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Lead your enemy when targeting with Noxious Blast to ensure the hit.

Playing against Cassiopeia

Be wary of Cassiopeia's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia when she is casting Petrifying Gaze to get slowed instead of stunned.

Guides

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Matchups

All Cassiopeia matchups

Strong against

Malzahar66.7%33
Zed54.5%33
Katarina52.9%34
Yone51.9%54
Yasuo47.6%82

Weak against

Vladimir22.2%27
Veigar28.6%21
Fizz40.0%25
Ahri41.2%34
Akali42.9%21

Abilities

P
Serpentine Grace
All Move Speed bonuses are more effective on Cassiopeia.
Q
Noxious Blast
Cassiopeia blasts an area with Poison after a brief delay, granting her increased Move Speed if she hits an enemy champion.
Cooldown: 3.5Cost: 50/55/60/65/70Range: 850
W
Miasma
Cassiopeia releases several clouds of poison, slowing, grounding, and lightly damaging enemies that pass through them. Grounded enemies cannot use Movement abilities.
Cooldown: 24/22/20/18/16Cost: 70/75/80/85/90Range: 700
E
Twin Fang
Cassiopeia lets loose an attack that deals increased damage to Poisoned targets and heals her for a percentage of the damage dealt. If the target dies from this attack, Cassiopeia regains Mana.
Cooldown: 0.75Cost: 45Range: 700
R
Petrifying Gaze
Cassiopeia releases a swirl of magical energy from her eyes, stunning any enemies in front of her that are facing her and slowing any others with their back turned.
Cooldown: 120/100/80Cost: 100Range: 825